Document Detail

Neurofibromatosis, stroke and basilar impression. Case report.
MedLine Citation:
PMID:  10450358     Owner:  NLM     Status:  MEDLINE    
Neurofibromatosis type 1 (NF1) can virtually affect any organ, presenting most frequently with "cafe au lait" spots and neurofibromas. Vasculopathy is a known complication of NF1, but cerebrovascular disease is rare. We report the case of a 51-year-old man admitted to the hospital with a history of stroke four months before admission. On physical examination, he presented various "cafe au lait" spots and cutaneous neurofibromas. Neurologic examination demonstrated right-sided facial paralysis, right-sided hemiplegia, and aphasia. Computed tomography scan of head showed hypodense areas in the basal ganglia and centrum semiovale. Radiographs of cranium and cervical spine showed basilar impression. Angiography revealed complete occlusion of both vertebral and left internal carotid arteries, and partial stenosis of the right internal carotid artery. A large network of collateral vessels was present (moyamoya syndrome). It is an uncommon case of occlusive cerebrovascular disease associated with NF1, since most cases described in the literature are in young people, and tend to spare the posterior cerebral circulation. Basilar impression associated with this case may be considered a pure coincidence, but rare cases of basilar impression and NF1 have been described.
E J Piovesan; R H Scola; L C Werneck; V H Zétola; E M Nóvak; F M Iwamoto; L M Piovesan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  57     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-10-12     Completed Date:  1999-10-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  484-8     Citation Subset:  IM    
Internal Medicine Department, Hospital de Clinicas of Federal University of Parana, Brasil.
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MeSH Terms
Cerebrovascular Disorders / diagnosis,  etiology*
Middle Aged
Moyamoya Disease
Neurofibromatosis 1 / complications*,  diagnosis
Platybasia / diagnosis,  etiology*

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