| Neurofibromatosis and pregnancy. An update. | |
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MedLine Citation:
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PMID: 8277488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurofibromatosis is one of the most frequent genetic diseases in humans. Pregnancy in neurofibromatosis patients is, however, less common. Most current information on pregnancy and neurofibromatosis is derived from case reports, which may not reflect the true situation. In the past 15 years only two series of pregnant neurofibromatosis patients were reported in the English-language literature. We present our experience with 34 pregnancies in nine neurofibromatosis patients who delivered at our medical center. While fertility does not seem to be impaired in neurofibromatosis, these patients experience a higher-than-expected rate of first-trimester spontaneous abortions (20.7%), stillbirths (8.7%) and intrauterine growth retardation (13.0%). A high rate of cesarean section (26%) was also observed in our series. We conclude that pregnant neurofibromatosis patients constitute a high-risk group, in danger of developing life-threatening complications. However, with proper antenatal care, most pregnant neurofibromatosis patients can deliver safety if the pregnancy continues beyond the first trimester. |
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Authors:
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A Weissman; P Jakobi; I Zaidise; A Drugan |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 38 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-02-07 Completed Date: 1994-02-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 890-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Rambam Medical Center, Technion-Faculty of Medicine, Haifa, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Neurofibromatoses* / diagnosis, therapy Pregnancy Pregnancy Complications, Neoplastic* / therapy Pregnancy Outcome / epidemiology* |
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