Document Detail

Neurofibromatosis and pregnancy: a report of maternal cardiopulmonary compromise.
MedLine Citation:
PMID:  20664435     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neurofibromatosis is a rare pregnancy complication that can present with rapidly enlarging masses that have malignant potential. CASE: A 19-year-old primagravid woman with a known history of neurofibromatosis presented in her first trimester with pulmonary complaints. A malignant mediastinal mass was diagnosed and resected, with additional treatment options declined. In less than 3 months, the patient presented with a recurrent mass that resulted in fatal airway compromise during the same gestation. CONCLUSION: Neurofibromatosis type 1 with malignant peripheral nerve sheath tumors complicating pregnancy requires an experienced, multidisciplinary team of care offering an aggressive evaluation to rule out malignant transformation or recurrence when there is any change in clinical status of a patient, as this may signal a potentially fatal change in the lesion.
David B Nelson; Laura Greer; George Wendel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116 Suppl 2     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas, USA.
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MeSH Terms
Airway Obstruction / etiology*
Fatal Outcome
Mediastinal Neoplasms / complications*
Neoplasm Recurrence, Local / complications*
Nerve Sheath Neoplasms / complications*
Neurofibromatosis 1 / complications*
Pregnancy Complications, Neoplastic*
Pregnancy Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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