Document Detail


Neurofibromatosis and other disorders among children with CNS tumors and their families.
MedLine Citation:
PMID:  2494566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a population-based case-control study with 338 patients, less than 15 years of age, diagnosed with a primary tumor of the central nervous system from January 1968 through December 1977 in 53 New York State counties. The study also included 676 controls selected from the birth certificate files of the New York State Department of Health. We collected information on neurofibromatosis and congenital anomalies in study subjects, their siblings and parents by telephone interview with the mother of each case and control. We obtained supplemental information on neurofibromatosis in the patients and their families from hospital medical records. This study confirmed the strong association of neurofibromatosis with risk of CNS tumors. Thirteen cases and no controls had neurofibromatosis. Two fathers and 3 mothers of cases had neurofibromatosis. Five cases had siblings with neurofibromatosis. None of the first-degree relatives of controls had neurofibromatosis. We observed a relative risk of 4.49 for history of seizures. Seizures are often among the presenting symptoms for CNS tumors. We observed no difference between cases and controls in the occurrence of congenital anomalies. There was a nonsignificant excess of congenital anomalies among siblings of cases compared with controls. This decreased to 1.13 when adjusted for number of siblings.
Authors:
M Baptiste; P Nasca; B Metzger; N Field; P MacCubbin; P Greenwald; V Armbrustmacher; J Waldman; K Carlton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  39     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-10     Completed Date:  1989-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-92     Citation Subset:  AIM; IM    
Affiliation:
Division of Epidemiology, New York State Department of Health, Albany 12237.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / complications,  genetics*
Child
Congenital Abnormalities / genetics*
Epidemiologic Methods
Female
Humans
Male
Neurofibromatosis 1 / complications,  genetics*
Spinal Cord Neoplasms / complications,  genetics*
Grant Support
ID/Acronym/Agency:
1 RO CA 26194/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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