Document Detail

Neurofibromatosis involving the small bowel associated with adenocarcinoma of the ileum with a neuroendocrine component.
MedLine Citation:
PMID:  1300607     Owner:  NLM     Status:  MEDLINE    
A patient with neurofibromatosis involving the small bowel who developed adenocarcinoma in an area of the ileum showing diffuse involvement of the disease is presented. Unlike the five cases with this association previously described, the present case shows a neuroendocrine component within the adenocarcinoma. The relation between neurofibromatosis of the bowel wall and adenocarcinoma may be explained by a decreased intestinal transit time in this patient. The presence of a carcinoid tumor in the ileum is not unusual in a patient with von Recklinghausen's disease, although the location of the carcinoid in the duodenum is described more frequently in these patients. The appearance of endocrine/neuroendocrine features within an adenocarcinoma already involved by diffuse neurofibromatosis is exceptional and may not be a chance event.
D Benharroch; N Sion-Vardi; J Goldstein
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pathology, research and practice     Volume:  188     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  959-63     Citation Subset:  IM    
Institute of Pathology, Soroka Medical Center, Beer-Sheva, Israel.
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MeSH Terms
Adenocarcinoma / pathology*
Carcinoid Tumor / pathology*
Ileal Neoplasms / pathology
Intestine, Small / pathology*
Microscopy, Electron
Neurofibromatoses / pathology*

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