Document Detail

Neurofibromatosis and childhood leukemia.
MedLine Citation:
PMID:  96239     Owner:  NLM     Status:  MEDLINE    
Twelve new cases of childhood leukemia and neurofibromatosis were ascertained and evaluated in conjunction with 17 previously well-documented cases. The ratio of ALL:nonlymphocytic leukemia was 9:20, markedly different from the 4:1 ratio in children without NF. Rarer subtypes predominated: 8 CML and 8 AMML. The peculiar distribution of leukemia by cell type and the number of cases observed in the United States indicate that the risk of childhood leukemia in NF is increased. Two possible variants were noted: NF with "transient leukemia," and multiple skin xanthomas with nonlymphocytic leukemia.
J L Bader; R W Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  92     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-9     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Leukemia / etiology*
Leukemia, Lymphoid / etiology,  genetics
Leukemia, Myeloid / etiology,  genetics
Leukemia, Myeloid, Acute / etiology,  genetics
Neurofibromatosis 1 / complications*,  genetics
Skin Diseases / etiology,  genetics
Xanthomatosis / etiology,  genetics

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