Document Detail


Neurofibromatosis and acute monocytic leukemia in adults.
MedLine Citation:
PMID:  2507124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient with nonfamilial peripheral neurofibromatosis (NF) (von Recklinghausen's disease) is reported who contracted acute monocytic leukemia at 60 years of age. In the course of the illness, myelonecrosis developed and the patient died 4 months later due to a therapy-resistant bone marrow relapse. This association of the two illnesses would appear to confirm reports on an increased incidence of nonlymphatic leukemia and NF. Such an association is seen during childhood as juvenile chronic leukemia, but it is uncommon in adulthood.
Authors:
C Goerg; K Goerg; K H Pflueger; K Havemann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  64     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1717-9     Citation Subset:  AIM; IM    
Affiliation:
Zentrum Innere Medizin, Philipps-Universitat, Abt. Hämatologie/Onkologie, Marburg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Blotting, Southern
Cytarabine / administration & dosage
Daunorubicin / administration & dosage
Humans
Leukemia, Monocytic, Acute / drug therapy,  pathology*
Male
Middle Aged
Neoplasms, Multiple Primary*
Neurofibromatosis 1 / drug therapy,  genetics,  pathology*
Thioguanine / administration & dosage
Chemical
Reg. No./Substance:
0/DAT protocol 1; 147-94-4/Cytarabine; 154-42-7/Thioguanine; 20830-81-3/Daunorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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