Document Detail

Neurofibromatosis 1 and multiple sclerosis.
MedLine Citation:
PMID:  7745407     Owner:  NLM     Status:  MEDLINE    
Neurofibromatosis 1 is a common autosomal dominant disease that principally involves the skin and peripheral nervous system. The gene for the disorder has been located on chromosome 17q11.2 and there are three embedded genes within the neurofibrosis gene. One of these genes codes for oligodendrocyte-myelin glycoprotein, is found in the CNS during myelination, and may have a role in myelin formation. The case histories of five patients, including two siblings, who have both neurofibromatosis 1 and multiple sclerosis are reported. All five had the primary progressive form of multiple sclerosis, which forms only 15% of multiple sclerosis in population surveys. The coincidence of neurofibromatosis 1 and multiple sclerosis might be due to a mutation in the embedded oligodendrocyte-myelin glycoprotein gene.
R E Ferner; R A Hughes; M R Johnson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  58     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-15     Completed Date:  1995-06-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  582-5     Citation Subset:  IM    
Department of Neurology, UMDS, Guy's Hospital, London, UK.
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MeSH Terms
Brain / pathology,  radiography
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis / complications*,  diagnosis,  genetics
Neurofibromatosis 1 / complications*,  diagnosis,  genetics
Tomography, X-Ray Computed

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