| Neurofibrillary tangles in association with congenital hydrocephalus. | |
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MedLine Citation:
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PMID: 3669082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphologic study of the brain from a retarded patient with progressive congenital hydrocephalus revealed widespread neurofibrillary tangles in the cerebral cortex and the brain stem. Senile plaques were not found. The tangles consisted of paired helical filaments. Scanning electron microscopic energy spectrometric analysis failed to demonstrate abnormal accumulation of aluminum or other elements in the involved neurons.For the first time the association of congenital hydrocephalus and neurofibrillary tangles is reported. This observation is consistent with the hypothesis of interference with axonal transport of neurofilaments as a common pathogenetic mechanism in the genesis of neurofibrillary tangles in human brains. |
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Authors:
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K J Fan; G Pezeshkpour |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 79 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-12-09 Completed Date: 1987-12-09 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1001-3, 1006 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Stem / pathology* Cerebral Cortex / pathology* Female Humans Hydrocephalus / pathology* Microscopy, Electron Neurofibrils / ultrastructure* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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