Document Detail


Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine.
MedLine Citation:
PMID:  7435167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of maytansine, an antimitotic compound isolated from an African plant, were studied by light and electron microscopy in dissociated cell cultures of adult mouse dorsal root ganglia. Maytansine at 10-100 ng/ml concentration caused reversible, concentration-dependent, inhibition of microtubule assembly and induction of a large amount of 10 nm filaments in the cytoplasm of cultured neurons and Schwann cells.
Authors:
S U Kim; M Tomonaga; B Ghetti
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neuropathologica     Volume:  52     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Ganglia, Spinal / pathology
Maytansine*
Mice
Microscopy, Electron
Microtubules / ultrastructure
Nerve Degeneration*
Neurons / pathology*,  ultrastructure
Oxazines*
Schwann Cells / ultrastructure
Grant Support
ID/Acronym/Agency:
NS-00151/NS/NINDS NIH HHS; NS-10648/NS/NINDS NIH HHS; NS-15205/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Oxazines; 35846-53-8/Maytansine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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