Document Detail

Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks.
MedLine Citation:
PMID:  8098663     Owner:  NLM     Status:  MEDLINE    
A current hypothesis for migraine suggests that neuroexcitatory amino acids may participate in the triggering of attacks. To investigate this possibility we measured glutamic and aspartic acid level in plasma and cerebrospinal fluid (CSF) of patients with common and classic migraine during attacks, making comparisons with controls suffering stress. Plasma levels of amino acids in migraine patients were lower than in controls. CSF concentrations of glutamic acid were higher in migraineurs than in controls. Our results suggest an excess of neuroexcitatory amino acids in the CNS of migraine patients during attacks, possibly favoring a state of neuronal hyperexcitability.
F Martínez; J Castillo; J R Rodríguez; R Leira; M Noya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  13     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-22     Completed Date:  1993-06-22     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Department of Neurology, Hospital General de Galicia-Clínico Universitario, Santiago de Compostela, Spain.
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MeSH Terms
Aspartic Acid / blood*,  cerebrospinal fluid*
Glutamates / blood*,  cerebrospinal fluid*
Glutamic Acid
Migraine Disorders / blood*,  cerebrospinal fluid*,  complications
Nervous System Diseases / etiology
Reference Values
Reg. No./Substance:
0/Glutamates; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid

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