| Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks. | |
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MedLine Citation:
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PMID: 8098663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A current hypothesis for migraine suggests that neuroexcitatory amino acids may participate in the triggering of attacks. To investigate this possibility we measured glutamic and aspartic acid level in plasma and cerebrospinal fluid (CSF) of patients with common and classic migraine during attacks, making comparisons with controls suffering stress. Plasma levels of amino acids in migraine patients were lower than in controls. CSF concentrations of glutamic acid were higher in migraineurs than in controls. Our results suggest an excess of neuroexcitatory amino acids in the CNS of migraine patients during attacks, possibly favoring a state of neuronal hyperexcitability. |
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Authors:
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F Martínez; J Castillo; J R Rodríguez; R Leira; M Noya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 13 ISSN: 0333-1024 ISO Abbreviation: Cephalalgia Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-06-22 Completed Date: 1993-06-22 Revised Date: 2008-02-11 |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: NORWAY |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: IM |
Affiliation:
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Department of Neurology, Hospital General de Galicia-Clínico Universitario, Santiago de Compostela, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / blood*, cerebrospinal fluid* Female Glutamates / blood*, cerebrospinal fluid* Glutamic Acid Humans Male Migraine Disorders / blood*, cerebrospinal fluid*, complications Nervous System Diseases / etiology Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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