| Neuroestrogens rapidly regulate sexual motivation but not performance. | |
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MedLine Citation:
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PMID: 23283331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogens exert pleiotropic effects on reproductive traits, which include differentiation and activation of reproductive behaviors and the control of the secretion of gonadotropins. Estrogens also profoundly affect non-reproductive traits, such as cognition and neuroprotection. These effects are usually attributed to nuclear receptor binding and subsequent regulation of target gene transcription. Estrogens also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. How these two types of actions that operate in distinct timescales interact in the control of complex behavioral responses is poorly understood. Here, we show that the central administration of estradiol rapidly increases the expression of sexual motivation, as assessed by several measures of sexual motivation produced in response to the visual presentation of a female but not sexual performance in male Japanese quail. This effect is mimicked by membrane-impermeable analogs of estradiol, indicating that it is initiated at the cell membrane. Conversely, blocking the action of estrogens or their synthesis by a single intracerebroventricular injection of estrogen receptor antagonists or aromatase inhibitors, respectively, decreases sexual motivation within minutes without affecting performance. The same steroid has thus evolved complementary mechanisms to regulate different behavioral components (motivation vs performance) in distinct temporal domains (long- vs short-term) so that diverse reproductive activities can be properly coordinated to improve reproductive fitness. Given the pleiotropic effects exerted by estrogens, other responses controlled by these steroids might also depend on a slow genomic regulation of neuronal plasticity underlying behavioral activation and an acute control of motivation to engage in behavior. |
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Authors:
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Aurore L Seredynski; Jacques Balthazart; Virginie J Christophe; Gregory F Ball; Charlotte A Cornil |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 33 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-03 Completed Date: 2013-03-12 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 164-74 Citation Subset: IM |
Affiliation:
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Research Group in Behavioral Neuroendocrinology, University of Liège, 4000 Liège, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aromatase / metabolism* Aromatase Inhibitors / pharmacology Brain / drug effects*, metabolism Coturnix Estradiol / analogs & derivatives, pharmacology* Estrogen Antagonists / pharmacology Female Male Motivation / drug effects*, physiology Neurons / drug effects, metabolism Sexual Behavior, Animal / drug effects*, physiology Tamoxifen / pharmacology Testosterone / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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MH50388/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aromatase Inhibitors; 0/Estrogen Antagonists; 10540-29-1/Tamoxifen; 22X328QOC4/fulvestrant; 50-28-2/Estradiol; 58-22-0/Testosterone; EC 1.14.14.1/Aromatase |
| Comments/Corrections | |
Erratum In:
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J Neurosci. 2013 Mar 6;33(10):4623 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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