Document Detail


Neuroestrogens rapidly regulate sexual motivation but not performance.
MedLine Citation:
PMID:  23283331     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estrogens exert pleiotropic effects on reproductive traits, which include differentiation and activation of reproductive behaviors and the control of the secretion of gonadotropins. Estrogens also profoundly affect non-reproductive traits, such as cognition and neuroprotection. These effects are usually attributed to nuclear receptor binding and subsequent regulation of target gene transcription. Estrogens also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. How these two types of actions that operate in distinct timescales interact in the control of complex behavioral responses is poorly understood. Here, we show that the central administration of estradiol rapidly increases the expression of sexual motivation, as assessed by several measures of sexual motivation produced in response to the visual presentation of a female but not sexual performance in male Japanese quail. This effect is mimicked by membrane-impermeable analogs of estradiol, indicating that it is initiated at the cell membrane. Conversely, blocking the action of estrogens or their synthesis by a single intracerebroventricular injection of estrogen receptor antagonists or aromatase inhibitors, respectively, decreases sexual motivation within minutes without affecting performance. The same steroid has thus evolved complementary mechanisms to regulate different behavioral components (motivation vs performance) in distinct temporal domains (long- vs short-term) so that diverse reproductive activities can be properly coordinated to improve reproductive fitness. Given the pleiotropic effects exerted by estrogens, other responses controlled by these steroids might also depend on a slow genomic regulation of neuronal plasticity underlying behavioral activation and an acute control of motivation to engage in behavior.
Authors:
Aurore L Seredynski; Jacques Balthazart; Virginie J Christophe; Gregory F Ball; Charlotte A Cornil
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-03-12     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Affiliation:
Research Group in Behavioral Neuroendocrinology, University of Liège, 4000 Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatase / metabolism*
Aromatase Inhibitors / pharmacology
Brain / drug effects*,  metabolism
Coturnix
Estradiol / analogs & derivatives,  pharmacology*
Estrogen Antagonists / pharmacology
Female
Male
Motivation / drug effects*,  physiology
Neurons / drug effects,  metabolism
Sexual Behavior, Animal / drug effects*,  physiology
Tamoxifen / pharmacology
Testosterone / pharmacology
Grant Support
ID/Acronym/Agency:
MH50388/MH/NIMH NIH HHS; R01 MH050388/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Estrogen Antagonists; 10540-29-1/Tamoxifen; 22X328QOC4/fulvestrant; 50-28-2/Estradiol; 58-22-0/Testosterone; EC 1.14.14.1/Aromatase
Comments/Corrections
Erratum In:
J Neurosci. 2013 Mar 6;33(10):4623

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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