Document Detail

Neuroendocrine tumors of the uterine cervix. Clinicopathologic study of five patients.
MedLine Citation:
PMID:  10817879     Owner:  NLM     Status:  MEDLINE    
Four main clinicopathologic features of neuroendocrine tumors (NETs) of the cervix may be stressed: primary diagnosis at an advanced stage, early nodal metastasis even for low disease, early failure of appropriate local treatment (surgery and/or radiation therapy) and aggressive clinical treatment. Five patients with NET of the uterine cervix (small cell carcinoma type) are reported (one stage I, two stages II, one stage III and one stage IV). One patient was treated by surgery combined with radiation therapy, one by surgery combined with chemotherapy and one by surgery with radiation therapy and chemotherapy. Two patients received radiation therapy alone. Three early stage patients are alive with no evidence of disease 8, 26 and 41 months after diagnosis. The two patients with advanced stage died of disease, 3 and 12 months respectively, after diagnosis. Combination chemotherapy (cisplatin and etoposide) is warranted in disseminated NETs. Neoadjuvant or adjuvant chemotherapy should be combined with radiation therapy and surgery even in early stages.
P Collinet; D Lanvin; D Declerck; A Chevalier-Place; E Leblanc; D Querleu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  91     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-08     Completed Date:  2000-08-08     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Hôpital Jeanne de Flandre, Pôle de Chirurgie Gynécologique, Clinique de Gynécologie-Obstétrique et Néonatalogie, CHRU Lille, 2 Avenue Oscar Lambret, 59037, Lille, France.
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MeSH Terms
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carcinoma, Small Cell / pathology,  therapy
Combined Modality Therapy
Hysterectomy / methods
Middle Aged
Neuroendocrine Tumors / drug therapy,  pathology*,  radiotherapy
Uterine Cervical Neoplasms / pathology*,  therapy

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