Document Detail

Neuroendocrine responses to intravenous L-tryptophan in obsessive compulsive disorder.
MedLine Citation:
PMID:  7829769     Owner:  NLM     Status:  MEDLINE    
We studied the neuroendocrine responses produced by intravenous L-tryptophan (TRP) in 16 untreated patients with obsessive compulsive disorder (OCD) and 16 matched healthy controls. The increase in plasma growth hormone seen following TRP was significantly greater in the OCD patients, while TRP-induced prolactin release did not differ from controls. Taken in conjunction with findings from other neuroendocrine studies the data suggest that some aspects of 5-HT1A neurotransmission may be increased in OCD. This increase may represent a compensatory change which promotes adaptation to stress in non-depressed OCD patients.
N A Fineberg; P J Cowen; J W Kirk; S A Montgomery
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of affective disorders     Volume:  32     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Academic Department of Psychiatry, St Mary's Hospital, London, UK.
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MeSH Terms
Arousal / physiology
Growth Hormone / blood*
Middle Aged
Obsessive-Compulsive Disorder / blood,  diagnosis*,  psychology
Prolactin / blood*
Receptors, Serotonin / physiology
Reference Values
Tryptophan / diagnostic use*
Reg. No./Substance:
0/Receptors, Serotonin; 73-22-3/Tryptophan; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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