| Neuroendocrine responses to hypoglycemia. | |
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MedLine Citation:
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PMID: 21039590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of hypoglycemia. Diabetes, both type 1 and type 2, can perturb these counterregulatory responses. Moreover, defective counterregulation in the setting of diabetes can progress to hypoglycemia unawareness. While the mechanisms that underlie the development of hypoglycemia unawareness are not completely known, possible causes include altered sensing of hypoglycemia by the brain and/or impaired coordination of responses to hypoglycemia. Further study is needed to better understand the intricacies of the counterregulatory response and the mechanisms contributing to the development of hypoglycemia unawareness. |
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Authors:
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Nolawit Tesfaye; Elizabeth R Seaquist |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-29 |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1212 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-14 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 12-28 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Department of Medicine, Division of Endocrinology and Diabetes, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Central Nervous System / metabolism, physiopathology Diabetes Mellitus, Type 1 / complications, metabolism, physiopathology Diabetes Mellitus, Type 2 / complications, metabolism, physiopathology Feedback, Physiological / physiology Humans Hypoglycemia / complications, diagnosis, physiopathology* Models, Biological Neurosecretory Systems / metabolism, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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2 T32 DK7203-33/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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