Document Detail


Neuroendocrine and reproductive effects of contemporary-use pesticides.
MedLine Citation:
PMID:  10188189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Work in our laboratory has focused on the hypothesis that certain environmental contaminants will interfere with reproductive function because they disrupt the neuroendocrine regulation of gonadal function. In this article, we review the evidence that certain classes of contemporary-use pesticides alter gonadotropin secretion through a disruption of hypothalamic mechanisms. Specifically, we discuss the effect of formamidine and dithiocarbamate pesticides on the noradrenergic control of pituitary hormone secretion, ovarian function, and pregnancy in the rat. This is followed by a review of studies evaluating the effect of a chlorotriazine herbicide, atrazine, on the hormonal control of ovulation and lactation. We also discuss the physiological consequences of these endocrine alterations in the female, how toxicant-induced endocrine alterations may differ in physiological outcome in the male and female, and the fact that the reproductive risk assessment of some pesticides that act on the central nervous system (CNS) may be influenced by the development of tolerance.
Authors:
R L Cooper; J M Goldman; T E Stoker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology and industrial health     Volume:  15     ISSN:  0748-2337     ISO Abbreviation:  Toxicol Ind Health     Publication Date:    1999 Jan-Mar
Date Detail:
Created Date:  1999-05-25     Completed Date:  1999-05-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-36     Citation Subset:  IM    
Affiliation:
Endocrinology Branch, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. cooper.ralph@epamail.epa.gov
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MeSH Terms
Descriptor/Qualifier:
Amidines / pharmacology,  toxicity*
Animals
Carbamates*
Central Nervous System / drug effects
Female
Gonadotropins / pharmacology,  secretion
Hypothalamo-Hypophyseal System / drug effects*,  physiology
Insecticides / pharmacology,  toxicity*
Male
Ovary / drug effects*,  physiology
Pregnancy / drug effects
Rats
Reproduction / drug effects
Risk Assessment
Chemical
Reg. No./Substance:
0/Amidines; 0/Carbamates; 0/Gonadotropins; 0/Insecticides; 463-52-5/formamidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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