Document Detail


Neuroendocrine regulation of anterior pituitary function in patients during and after molar pregnancy.
MedLine Citation:
PMID:  3120449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Only partial studies evaluating the endocrine profile in molar pregnancy have been performed. In order to characterize the neuro-endocrine pattern during and after molar pregnancy, we studied the basal hormonal levels of hCG, human placental lactogen (hPL), FSH, GH, TSH, free thyroxine index (FTI), oestradiol-17 beta (E2), and progesterone (PG), as well as the anterior pituitary response to TRH, GnRH, and hypoglycaemia induced by insulin in 7 patients during molar pregnancy and one week after molar abortion. hCG showed significantly higher serum levels during rather than after molar pregnancy and hPL was detectable in only 4 patients during, but in none after molar pregnancy. FSH values were in the follicular phase range before and after molar abortion (12.7 +/- 0.8 and 12.7 +/- 3.5 IU/l). PRL had elevated basal levels before and after molar abortion; 103.0 +/- 16.5 and 43 +/- 10.6 micrograms/l, respectively (P less than 0.05). GH levels were distinctly elevated in 3 patients during molar pregnancy; after molar abortion, the basal GH values were normal in all patients less than 10 micrograms/l. Basal cortisol and TSH levels were in the normal range before and after molar abortion. The FTI was above the normal range in 3 patients during molar pregnancy, whereas after molar abortion the values were normalized. E2 levels were elevated before and after molar abortion, 1881 +/- 477 and 96.5 +/- 39.2 ng/l, respectively (P less than 0.01). PG levels before and after molar abortion were 30.9 +/- 5.4 and 10 +/- 6.7 micrograms/l, respectively (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
G Forsbach; J Contreras; R de Hoyos; A Martinez-Campos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  116     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  373-80     Citation Subset:  IM    
Affiliation:
Unidad de Investigacion Biomedica del Noreste, IMSS, Nuevo Leon, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chorionic Gonadotropin / blood
Estradiol / blood
Female
Follicle Stimulating Hormone / blood
Growth Hormone / blood
Humans
Hydatidiform Mole / metabolism*
Hydrocortisone / blood
Hypoglycemia
Pituitary Gland, Anterior / metabolism*
Pituitary Hormone-Releasing Hormones / pharmacology
Pregnancy
Progesterone / blood
Prolactin / blood
Thyrotropin-Releasing Hormone / pharmacology
Thyroxine / blood
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Pituitary Hormone-Releasing Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57-83-0/Progesterone; 7488-70-2/Thyroxine; 9002-62-4/Prolactin; 9002-68-0/Follicle Stimulating Hormone; 9002-72-6/Growth Hormone

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