Document Detail

Neuroendocrine mediators in the modulation of phagocytosis by exercise: physiological implications.
MedLine Citation:
PMID:  14686096     Owner:  NLM     Status:  MEDLINE    
Neuroendocrine mediation of the effects of exercise on macrophage and neutrophil phagocytosis, the organism's first line of defense against external aggression, is reviewed. Exercise modulates the immune system via the actions of "stress hormones". Although stress had long been regarded as generally immunosuppressive, it is now accepted that this is not always true. Indeed exercise-induced stress stimulates the "phagocytic process" of phagocytes. One of the new physiological interpretations emerging from recent studies is that the general stimulation of phagocytosis and other innate mechanisms during strenuous physical activity may counterbalance the decreased lymphoid activity, preventing the entry and survival of microorganisms in situations where the specific responses are depressed. In some cases this behaviour is also medicated by "stress hormones", unlike in lymphocytes in which glucocorticoids and catecholamines both are immunosuppressive. The mediatory role of glucocorticoids in macrophages may also differ between the non-specific functions, like chemotaxis and phagocytosis, and the more specific ones, like antigen-presentation. Neutrophils and monocytes may be stimulated by catecholamines or sympathetic signals, and variations in phagocytosis and catecholamines have been proposed as a good "neuroimmuno-endocrinological marker" in athletes. Other hormones (prolactin, GH, endorphins, thyroid hormones) in general also contribute to the effects of exercise-stress on phagocytosis. This review focuses on a physiological interpretation of the immune response to exercise which differs markedly from the classical immunosuppression-centered view. More studies on in vivo variations of stress hormones during exercise are needed.
Eduardo Ortega
Related Documents :
6737326 - Extracranial vascular changes during headache, exercise and stress.
11707916 - Longevity and aging: beneficial effects of exposure to mild stress.
10681886 - Protective and damaging effects of mediators of stress. elaborating and testing the con...
15863086 - Influence of spine morphology on intervertebral disc loads and stresses in asymptomatic...
3670906 - Recovery from hypopnea in preterm lambs: effects of breathing air or oxygen.
12182216 - Speech motor control and acute mountain sickness.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Exercise immunology review     Volume:  9     ISSN:  1077-5552     ISO Abbreviation:  Exerc Immunol Rev     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-02-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9505535     Medline TA:  Exerc Immunol Rev     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  70-93     Citation Subset:  IM    
Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071-Badajoz, España.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Catecholamines / physiology
Exercise / physiology*
Glucocorticoids / physiology
Growth Hormone / physiology
Macrophages / immunology
Neurosecretory Systems / physiology*
Neutrophils / immunology
Phagocytosis / physiology*
Reg. No./Substance:
0/Catecholamines; 0/Glucocorticoids; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microarray technology--the future analyses tool in exercise physiology?
Next Document:  Evidence-based medicine: why clinical ethicists should be concerned.