Document Detail

Neuroendocrine mechanisms involved in regulation of body weight, food intake and metabolism.
MedLine Citation:
PMID:  2234609     Owner:  NLM     Status:  MEDLINE    
Body weight regulation is the result of food intake and energy expenditure. The central nervous system (CNS), and in particular, the hypothalamus, controls food intake as well as metabolism, the latter mainly by autonomic effects on the islet of Langerhans, hepatocytes and adipocytes. Body weight, more precisely body fat content, is probably controlled by a feedback mechanism in which insulin, released from the B cell of the islet of Langerhans, plays a key role. The islet of Langerhans is an intricate neuroendocrine unit in which the release of glucagon, insulin, and somatostatin from A, B, and D cells, respectively, is controlled by the CNS via a rich autonomic innervation. In addition, the endocrine cells of the pancreas influence each other by paracrine actions. The CNS control of the islets shapes the plasma insulin and blood glucose profiles during the circadian cycle and thereby regulates the nutrient flow to the different tissues in the body. Thus, the CNS structures involved in regulation of body weight and food intake control also metabolism. The mechanisms contributing to match food intake and the needs of metabolism are discussed.
A B Steffens; J H Strubbe; B Balkan; J W Scheurink
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  14     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-05     Completed Date:  1990-12-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-13     Citation Subset:  IM    
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
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MeSH Terms
Body Weight / physiology*
Eating / physiology*
Metabolism / physiology*
Neurosecretory Systems / physiology*

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