| Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions. | |
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MedLine Citation:
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PMID: 18469673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hormones may influence susceptibility to develop seizures. The concept of the interrelation between epilepsy, hormones, and hormonotherapy is currently emerging. On the other hand, epilepsy and its medications are associated with hormonal disturbances resulting in altered endocrine reproduction and sexual functions. REVIEW SUMMARY: Epilepsy itself may directly influence the endocrine control centers in the brain, the hypothalamic-pituitary axis, thus altering the release of sex steroid hormones including the production of luteinizing hormone, follicle stimulating hormone, gonadotrophin-releasing hormone, and prolactin and the concentrations and metabolism of its end products such as estrogen, testosterone, and dehydroepiandrosterone. Antiepileptic drugs may modulate hormone release from the hypothalamic-pituitary-gonadal axis and may have direct inhibitory effect on reproductive function. They may change steroid sex hormones metabolism and their binding proteins. Reduced fertility and disturbance in various aspects of sexual function are common in men and women with epilepsy. Men with epilepsy may develop delayed sexual development, sperm, and testicular abnormalities. Women with epilepsy may develop menstrual disturbances, weight gain, hyperandrogenism, ovulatory failure, and polycystic ovaries. CONCLUSIONS: Epileptic patients will benefit from regular monitoring of ovarian and testicular functions. Early characterization of reproductive abnormalities encountered in patients with epilepsy will allow neurologists to properly choose and change antiepileptic medications. This will also improve patients' sexual function. |
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Authors:
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Sherifa Ahmed Hamed |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The neurologist Volume: 14 ISSN: 1074-7931 ISO Abbreviation: Neurologist Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-12 Completed Date: 2008-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503763 Medline TA: Neurologist Country: United States |
Other Details:
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Languages: eng Pagination: 157-69 Citation Subset: IM |
Affiliation:
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Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt. hamed_sherifa@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects Endocrine System Diseases / etiology, physiopathology* Epilepsy / complications, drug therapy, physiopathology* Gonadal Steroid Hormones / metabolism, secretion Gonads / drug effects, physiopathology Humans Hypothalamo-Hypophyseal System / physiopathology* Infertility / etiology, physiopathology Pituitary Diseases / etiology, physiopathology Sexual Dysfunction, Physiological / etiology*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Gonadal Steroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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