Document Detail

Neuroendocrine evidence of normal hypothalamus-pituitary dopaminergic function in Huntington's disease.
MedLine Citation:
PMID:  20588235     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In addition to neuronal loss in striatum and cerebral cortex that characterizes Huntington's disease (HD), hypothalamic atrophy has also been found only in certain areas, probably not including dopaminergic functions.
METHODS: We assessed the reactivity of the hypothalamus-pituitary dopaminergic system by measuring the acute prolactin (PRL) responses to 5 mg i.m. haloperidol in male and female HD patients and in female subjects with expanded CAG repeats in the Huntington gene before disease onset, as well as in a group of healthy males.
RESULTS: The responses of the male patients were similar to those of a group of male healthy volunteers. Females gave higher PRL responses, with no differences in the response patterns of female patients and females at risk for HD. PRL elevations were not related to severity of illness, or to presence of dementia, depression, or psychotic features.
CONCLUSIONS: The results implicate a normal dopaminergic input from hypothalamus to pituitary and preserved pituitary dopamine receptors, indicating that hypothalamic atrophy in HD does not affect mechanisms involved in PRL secretion by haloperidol.
Manolis Markianos; Marios Panas; Nikos Kalfakis; John Hatzimanolis; Dimitrios Vassilopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  31     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-10-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  IM    
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MeSH Terms
Dopamine / physiology*
Genetic Predisposition to Disease
Haloperidol / pharmacology
Huntington Disease / blood*,  genetics,  physiopathology*
Hypothalamo-Hypophyseal System / drug effects,  physiology*
Middle Aged
Nerve Tissue Proteins / genetics
Nuclear Proteins / genetics
Prolactin / blood*
Sex Characteristics
Trinucleotide Repeats
Reg. No./Substance:
0/HTT protein, human; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 9002-62-4/Prolactin; J6292F8L3D/Haloperidol; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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