Document Detail


Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence.
MedLine Citation:
PMID:  1654588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient with Kleine-Levin syndrome had polysomnography and neuroendocrinological assays performed during asymptomatic (ASMP) and symptomatic (SMP) 24-hr periods. During the SMP, sleep data revealed poor nocturnal sleep efficiency, increased sleep fragmentation and reduced stages 3, 4 and rapid eye movement (REM). No sleep onset REM episodes were seen. Sleep staging in the ASMP was normal. Blood samples were obtained every 20 min and assayed for thyroid-stimulating hormone (TSH), cortisol (CORT), prolactin (PRL) and growth hormone (GH). Patterns of secretion, 24-hr mean and total integrated concentrations, and mean sleep period time values during the ASMP and SMP were compared. The mean 24-hr level of TSH was increased and GH decreased in the SMP. Comparing sleep period time in the SMP to the ASMP, values for TSH and PRL were increased and GH and CORT were reduced in the SMP. These hormone changes support the hypothesis that reduced hypothalamic dopaminergic tone is present in the SMP compared to the ASMP in Kleine-Levin patients.
Authors:
A L Chesson; S N Levine; L S Kong; S C Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Sleep     Volume:  14     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-23     Completed Date:  1991-10-23     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Affiliation:
Neurology, Service, Louisiana State University Medical Center, Shreveport 71130-3932.
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MeSH Terms
Descriptor/Qualifier:
Adult
Disorders of Excessive Somnolence / physiopathology*
Dopamine / physiology*
Growth Hormone / blood
Humans
Hydrocortisone / blood
Hyperphagia / physiopathology
Hypothalamo-Hypophyseal System / physiopathology*
Hypothalamus / physiopathology
Male
Prolactin / blood
Receptors, Dopamine / physiology*
Sleep Stages / physiology*
Sleep, REM / physiology
Synaptic Transmission / physiology
Syndrome
Thyrotropin / blood
Chemical
Reg. No./Substance:
0/Receptors, Dopamine; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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