Document Detail

Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia.
MedLine Citation:
PMID:  12064868     Owner:  NLM     Status:  MEDLINE    
Patients with hypergastrinemia secondary to achlorhydria have an increased risk of developing ECL cell carcinoids and gastric adenocarcinomas. Hypergastrinemia is central in the pathogenesis of ECL cell carcinoids, but the link between gastrin and gastric carcinomas is controversial. During neoplastic transformation ECL cells may, however, lose many of their neuroendocrine characteristics, making them difficult to recognise as neuroendocrine with conventional immunohistochemical techniques. Neuroendocrine differentiation was therefore examined in eight gastric adenocarcinomas found in seven patients with severe hypergastrinemia and/or pernicious anemia using a monoclonal antibody towards chromogranin A and immunohistochemistry without and with a sensitive signal amplification technique. The Sevier-Munger method was used as a more specific marker of ECL cells. Seven of the carcinomas contained scattered neuroendocrine tumour cells. When using signal amplification, an increase in the number of immunoreactive neoplastic cells was seen. In many tumours, clusters or confluent sheets of such cells were disclosed, suggesting a neuroendocrine and ECL cell origin. These tumours may therefore be ECL cell carcinomas and hypergastrinemia may thus be involved in the tumourigenesis.
Gunnar Qvigstad; Tor Qvigstad; Bjørn Westre; Arne K Sandvik; Eiliv Brenna; Helge L Waldum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  110     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
Norwegian University of Science and Technology, Faculty of Medicine, Department of Intra-abdominal Diseases, Trondheim.
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MeSH Terms
Adenocarcinoma / blood,  complications,  pathology*
Anemia, Pernicious / complications*
Cell Differentiation
Chromogranin A
Chromogranins / analysis
Enterochromaffin-like Cells / pathology*
Gastrins / blood*
Neuroendocrine Tumors / blood,  pathology
Staining and Labeling
Stomach Neoplasms / blood,  complications,  pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Chromogranin A; 0/Chromogranins; 0/Gastrins; 0/Tumor Markers, Biological

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