Document Detail


Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight.
MedLine Citation:
PMID:  18928406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stress affects the gastrointestinal tract as part of the visceral response. Various stressors induce similar profiles of gut motor function alterations, including inhibition of gastric emptying, stimulation of colonic propulsive motility, and hypersensitivity to colorectal distension. In recent years, substantial progress has been made in our understanding of the underlying mechanisms of stress's impact on gut function. Activation of corticotropin-releasing factor (CRF) signaling pathways mediates both the inhibition of upper gastrointestinal (GI) and the stimulation of lower GI motor function through interaction with different CRF receptor subtypes. Here, we review how various stressors affect the gut, with special emphasis on the central and peripheral CRF signaling systems.
Authors:
Andreas Stengel; Yvette Taché
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  71     ISSN:  1545-1585     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-09-22     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Corticotropin-Releasing Hormone / physiology
Gastrointestinal Motility / physiology
Gastrointestinal Tract / physiology*
Humans
Neurosecretory Systems / physiology*
Signal Transduction / physiology
Stress, Physiological / physiology*
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; DK57238/DK/NIDDK NIH HHS; P50 AR 049550/AR/NIAMS NIH HHS; R01 DK-33061/DK/NIDDK NIH HHS; R01 DK057238/DK/NIDDK NIH HHS; R01 DK057238-08/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

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