Document Detail

Neuroendocrine control of food intake.
MedLine Citation:
PMID:  15711218     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Obesity is a major public health problem and substantially increases the risk of type 2 diabetes, hypertension, stroke, cardiovascular, respiratory problems, gall bladder disease, osteoarthritis and sleep apnoea, as well as certain cancers. The prevalence of obesity is rapidly increasing worldwide. However, for individuals weight is regulated within a narrow range. This regulation depends on energy intake (in the form of food) and energy expenditure. Recently, there has been a remarkable increase in our understanding of the homeostatic mechanisms that control food intake and energy homeostasis. RECENT FINDINGS: There is increased understanding of the central regulation of appetite. In particular, this includes new knowledge about the hypothalamus and brainstem and their relation to food intake regulation. Peripheral hormones (notably adipostat factors and gut hormones) have now been found to be important in food intake regulation. SUMMARY: Complex central circuitry controls food intake. Circulating hormones, in particular the gut hormones have unexpectedly been found to be very important in appetite control. The gut hormones are thus new and exciting targets for future obesity therapies.
Adrian J Park; Stephen R Bloom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  21     ISSN:  0267-1379     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom.
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MeSH Terms
Appetite / physiology*
Eating / physiology*
Neurosecretory Systems / physiology*
Peptide Hormones / metabolism
Reg. No./Substance:
0/Peptide Hormones

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