| Neuroendocrine changes in chronic cardiac failure. | |
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MedLine Citation:
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PMID: 8896739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous hormonal and neuroendocrine changes have been described in patients with chronic cardiac failure. These affect the balance of vasodilator and vasoconstrictor factors in favour of the latter, to the detriment of the circulation. Whether this is a reaction to central cardiac (haemodynamic) abnormalities, or is an integral part of the syndrome of heart failure, remains to be determined. Catecholamine levels are increased, especially in severe heart failure, and contribute to the vasoconstriction and probably also to lethal ventricular arrhythmias. The renin-angiotensin-aldosterone system (RAAS) is also activated, causing fluid retention and further vasoconstriction. In the earlier stages, some of this increase may be iatrogenic due to the use of loop diuretics or inhibitors of angiotensin converting enzyme, but there is evidence for independent RAAS activation in more severe grades of heart failure. The role of vasoconstrictor peptides such as neuropeptide Y and endothelin is briefly considered. Counterbalancing these are vasodilator peptides, in particular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). The possibility of therapeutic interventions to increase circulating natriuretic hormone levels is discussed. |
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Authors:
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D P Nicholls; G N Onuoha; G McDowell; J S Elborn; M S Riley; A M Nugent; I C Steele; C Shaw; K D Buchanan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Basic research in cardiology Volume: 91 Suppl 1 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-28 Completed Date: 1997-01-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Victoria Hospital, Northern Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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blood Bombesin / blood Chronic Disease Glucagon / blood Heart Failure / blood, physiopathology* Humans Insulin / blood Neuropeptide Y / blood Neurosecretory Systems / physiopathology* Neurotensin / blood Renin-Angiotensin System |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 11061-68-0/Insulin; 31362-50-2/Bombesin; 39379-15-2/Neurotensin; 85637-73-6/Atrial Natriuretic Factor; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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