| Neuroendocrine cell hyperplasia of infancy: a prospective follow-up of nine children. | |
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MedLine Citation:
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PMID: 23161905 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Neuroendocrine cell hyperplasia of infancy (NEHI) has recently been described as an obstructive airway disease that affects infants aged 1-24 months, and presents typically with tachypnoea, crackles and hypoxia. The pathogenesis of the disease is unknown. We describe the clinical course of nine infants with radiologically and histologically confirmed NEHI. Host or environmental factors were not associated with the disease development. All infants with lung function tests demonstrated findings consistent with severe irreversible peripheral airway obstruction, assessed with whole body plethysmography (6/6) or the rapid thoracoabdominal compression technique (5/5). While the symptoms abated in all infants, six infants developed a non-atopic asthma during the follow-up. Systemic or inhaled corticosteroid treatment did not affect the duration of the symptoms. NEHI may mimic severe asthma and thus this entity should be taken into account when evaluating infants with chronic respiratory symptoms. |
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Authors:
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Heikki Lukkarinen; Anna Pelkonen; Jouko Lohi; Kristiina Malmström; L Pekka Malmberg; Merja Kajosaari; Harri Lindahl; Anna Föhr; Olli Ruuskanen; Mika J Mäkelä |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-17 |
Journal Detail:
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Title: Archives of disease in childhood Volume: - ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Turku University Central Hospital, , Turku, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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