Document Detail

Neuroendocrine cell hyperplasia of infancy: a prospective follow-up of nine children.
MedLine Citation:
PMID:  23161905     Owner:  NLM     Status:  Publisher    
Neuroendocrine cell hyperplasia of infancy (NEHI) has recently been described as an obstructive airway disease that affects infants aged 1-24 months, and presents typically with tachypnoea, crackles and hypoxia. The pathogenesis of the disease is unknown. We describe the clinical course of nine infants with radiologically and histologically confirmed NEHI. Host or environmental factors were not associated with the disease development. All infants with lung function tests demonstrated findings consistent with severe irreversible peripheral airway obstruction, assessed with whole body plethysmography (6/6) or the rapid thoracoabdominal compression technique (5/5). While the symptoms abated in all infants, six infants developed a non-atopic asthma during the follow-up. Systemic or inhaled corticosteroid treatment did not affect the duration of the symptoms. NEHI may mimic severe asthma and thus this entity should be taken into account when evaluating infants with chronic respiratory symptoms.
Heikki Lukkarinen; Anna Pelkonen; Jouko Lohi; Kristiina Malmström; L Pekka Malmberg; Merja Kajosaari; Harri Lindahl; Anna Föhr; Olli Ruuskanen; Mika J Mäkelä
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-17
Journal Detail:
Title:  Archives of disease in childhood     Volume:  -     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Turku University Central Hospital, , Turku, Finland.
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