Document Detail

Neuroendocrine carcinoma of the vagina in pregnancy.
MedLine Citation:
PMID:  22270433     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : Neuroendocrine carcinoma of the vagina is extremely rare. Treatment options in pregnancy are complex owing to the aggressive tumor type and poor prognosis.
CASE: : We report the case of a gravid woman diagnosed with stage IVB neuroendocrine carcinoma of the vagina at 16 weeks of gestation. Disease responded to chemotherapy, and pregnancy was continued until onset of preterm labor at 28 5/7 weeks of gestation, with subsequent delivery of a viable fetus. Despite aggressive treatment with chemoradiation postpartum, the patient died of progressive disease 11 months after initial diagnosis.
CONCLUSION: : A multidisciplinary team should review treatment options and potential complications with the patient. Because of the tendency toward early tumor dissemination, the optimal treatment for neuroendocrine carcinoma in pregnancy involves systemic chemotherapy.
Adam C Elnaggar; Avinash S Patil; Krishna Singh; Mark E Reed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  119     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-7     Citation Subset:  AIM; IM    
From the Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, and the Division of Gynecologic Oncology, University of Tennessee-West Clinic, Memphis, Tennessee; and the Divisions of Maternal-Fetal Medicine, Duke University Medical Center, Durham, North Carolina, and Cedars-Sinai Medical Center, Los Angeles, California.
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