Document Detail

Neuroendocrine carcinoma of the thymus: aspiration biopsy, immunocytochemistry, and clinicopathologic correlates.
MedLine Citation:
PMID:  7774498     Owner:  NLM     Status:  MEDLINE    
We report three cases of well-differentiated neuroendocrine carcinoma originating primarily in the anterior mediastinum which had been initially investigated by fine-needle aspiration cytology in conjunction with immunocytochemistry and subsequently recognized as thymic in origin. Aspirates consisted of loosely cohesive or aggregated medium sized elements with round to oval nuclei and scanty cytoplasm. In all cases the Romanowsky stain provided an excellent delineation of definite paranuclear inclusion-like structures having a semicircular or discoid appearance which appeared to contain cytokeratin by immunocytochemical studies and were very similar to the intermediate filament paranuclear "buttons" found in neuroendocrine Merkel cell carcinoma of the skin. This appears to be a novel cytologic observation for thymic neuroendocrine carcinoma. We discuss the significance of the above cytologic and immunocytochemical findings and their possible role in the diagnosis of thymic neuroendocrine carcinoma by fine-needle aspiration biopsy.
G Gherardi; C Marveggio; A Placidi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  12     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-11     Completed Date:  1995-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Department of Pathology, City Hospital of Sondrio, Italy.
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MeSH Terms
Antigens, Neoplasm / analysis
Biopsy, Needle
Carcinoma, Neuroendocrine / pathology*
Middle Aged
Thymus Neoplasms / pathology*
Reg. No./Substance:
0/Antigens, Neoplasm

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