Document Detail

Neuroendocrine and behavioral responses during conditioned active and passive behavior in the defensive burying/probe avoidance paradigm: effects of ipsapirone.
MedLine Citation:
PMID:  1355919     Owner:  NLM     Status:  MEDLINE    
Plasma epinephrine (E), norepinephrine (NE), and corticosterone (CORT) concentrations were determined in the rat before, during, and after a 15-min exposure to a nonelectrified probe on day after receiving electric shock (1.5 mA) through a probe mounted on the wall of the home cage. Rats displayed burying (active coping) if sawdust was provided on the floor and immobility (passive coping) if bedding was absent both during training and testing. The conditioned burying was accompanied by high plasma NE but low E and CORT concentrations, whereas immobility was associated with high CORT and low NE levels. A forced switch from the active to passive coping (training with and testing without sawdust) led to the highest rise in E concentration. The 5-HT1A agonist ipsapirone, with anxiolytic properties, dose-dependently (0.5 and 2.5 mg/kg, IV) reduced defensive burying behavior and increased the amount of time spent on feeding behavior in the presence of bedding material. Both plasma E and CORT levels were further elevated by the higher dose of ipsapirone. In the absence of bedding material, ipsapirone failed to affect immobility behavior, but it dose-dependently elevated the stress-induced increase in E, NE, and CORT concentrations. Accordingly, the behavioral anxiolytic action of the 5-HT1A agonist ipsapirone was restricted to active coping, whereas neuroendocrine activation by the drug was present in all conditions. It is suggested that the effects of ipsapirone on behavioral coping and neuroendocrine regulation are produced by different populations of 5-HT1A receptors in the brain.
S M Korte; G A Bouws; J M Koolhaas; B Bohus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  52     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
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MeSH Terms
Anti-Anxiety Agents / blood,  pharmacology*
Avoidance Learning / drug effects*
Behavior, Animal / drug effects*
Conditioning, Operant / drug effects*,  physiology*
Corticosterone / blood
Epinephrine / blood
Neurosecretory Systems / drug effects*
Norepinephrine / blood
Pyrimidines / blood,  pharmacology*
Rats, Inbred Strains
Receptors, Serotonin / drug effects
Serotonin / blood,  physiology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Pyrimidines; 0/Receptors, Serotonin; 50-22-6/Corticosterone; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 92589-98-5/ipsapirone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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