Document Detail

Neurodevelopmental outcomes of infants born prematurely.
MedLine Citation:
PMID:  16344661     Owner:  NLM     Status:  MEDLINE    
Long-term follow-up of infants born prematurely is necessary to determine neurodevelopmental outcomes, particularly with the expansion of interest from major disabilities to high prevalence/low severity dysfunctions. Models of pathogenesis include changes due to developmental disruptions and to injury, the magnitude and type of change influenced by the infant's age, and central nervous system recovery and reorganization. Alterations in neurogenesis, migration, myelination, cell death, and synaptogenesis occur even in the absence of insult. Despite increased knowledge regarding these processes, the functional significance of brain abnormalities is unclear. Because of methodologic problems in follow-up studies, it is difficult to characterize outcome definitively. Nonetheless, an acceptable degree of agreement across studies is found with regard to specific neurodevelopmental outcomes: motor/neurologic function, visuomotor integrative skills, IQ, academic achievement, language, executive function, and attention-deficit hyperactivity disorder/behavioral issues. In general, children born prematurely have more problems in these areas than do their normal birth weight counterparts. Suggestions for improved analyses and clarification of outcomes include use of cluster analysis, structural equation modeling, growth curve analysis, developmental epidemiologic approaches, and better control of background variables using risk indexes and factor scores. Better assessment techniques measuring functions documented to be at higher risk of problems are discussed.
Glen P Aylward
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  26     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-13     Completed Date:  2006-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-40     Citation Subset:  IM    
Division of Developmental and Behavioral Pediatrics, Southern Illinois University School of Medicine, Springfield 62794-9658, USA.
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MeSH Terms
Brain Diseases* / epidemiology,  etiology,  prevention & control
Developmental Disabilities* / epidemiology,  etiology,  prevention & control
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature*
Neuropsychological Tests
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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