Document Detail

Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum.
MedLine Citation:
PMID:  18307547     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). METHODS: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute-Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre-and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. RESULTS: Follow-up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. CONCLUSION: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow-up is necessary to look for moderate disabilities.
A Chadie; S Radi; L Trestard; A Charollais; D Eurin; E Verspyck; S Marret;
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Publication Detail:
Type:  Journal Article     Date:  2008-02-27
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  420-4     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale, AVENIR Research Group & Department of Neonatal Medicine and Intensive Care, Rouen Institute for Biomedical Research, University of Rouen, F-76183 Rouen, France.
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MeSH Terms
Child, Preschool
Corpus Callosum / abnormalities*
Developmental Disabilities / epidemiology*
Follow-Up Studies
Magnetic Resonance Imaging
Nervous System Diseases / epidemiology*
Ultrasonography, Prenatal*
P Fournet / ; G Labadie / ; V Barre / ; F Faggianelli / ; F Mokdad / ; M Cingotti / ; E Jeannot / ; S Chouchene / ; C Forget / ; S El Aïck / ; C Pascal / ; M Meunier / ; J Y Baril / ; B Louis-Juste / ; E Le Goupil / ; B Delaporte / ; H Bruel / ; J Le Long / ; I Lamy-Leriche / ; C Lambert / ; S Ba / ; B Thobois / ; F Levavasseur / ; S Capella-Allouc / ; D Ramassamy / ; M Rouha / ; P Lumbraso / ; L Marpeau / ; A Diguet / ; V Brossard /

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