| Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum. | |
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MedLine Citation:
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PMID: 18307547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). METHODS: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute-Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre-and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. RESULTS: Follow-up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. CONCLUSION: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow-up is necessary to look for moderate disabilities. |
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Authors:
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A Chadie; S Radi; L Trestard; A Charollais; D Eurin; E Verspyck; S Marret; |
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Publication Detail:
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Type: Journal Article Date: 2008-02-27 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 97 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-26 Completed Date: 2008-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 420-4 Citation Subset: IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale, AVENIR Research Group & Department of Neonatal Medicine and Intensive Care, Rouen Institute for Biomedical Research, University of Rouen, F-76183 Rouen, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Corpus Callosum / abnormalities* Developmental Disabilities / epidemiology* Follow-Up Studies Humans Intelligence Magnetic Resonance Imaging Nervous System Diseases / epidemiology* Ultrasonography, Prenatal* |
| Investigator | |
Investigator/Affiliation:
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P Fournet / ; G Labadie / ; V Barre / ; F Faggianelli / ; F Mokdad / ; M Cingotti / ; E Jeannot / ; S Chouchene / ; C Forget / ; S El Aïck / ; C Pascal / ; M Meunier / ; J Y Baril / ; B Louis-Juste / ; E Le Goupil / ; B Delaporte / ; H Bruel / ; J Le Long / ; I Lamy-Leriche / ; C Lambert / ; S Ba / ; B Thobois / ; F Levavasseur / ; S Capella-Allouc / ; D Ramassamy / ; M Rouha / ; P Lumbraso / ; L Marpeau / ; A Diguet / ; V Brossard / |
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