| Neurodevelopmental outcome in children born to mothers with hypertension in pregnancy: the significance of suboptimal intrauterine growth. | |
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MedLine Citation:
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PMID: 16483396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this investigation of 45 children born to mothers with hypertension in pregnancy, our objective was to examine the role of a fetal risk factor (suboptimal intrauterine growth [SOIUG]) in determining developmental outcome. There were two groups of children: Group 1 (n=26; 10 males, 16 females; mean testing age 56.77 mo [SD 13.03], range 41-82 mo; mean gestational age 32.96 wks [SD 2.24], range 27-38 wks; mean birthweight 1,984.42g [SD 563], range 1,046-3,515g) without, and Group 2 (n=19; 6 males, 13 females; mean testing age 57.63 mo [SD 14.86], range 40-84 mo; mean gestational age 34.21 wks [SD 2.10], range 29-39 wks, mean birthweight 1,572g [SD 365], range 855-2,690g) with SOIUG. We found that SOIUG was associated with a significant reduction in cognitive and motor skills (p<0.05). Visuospatial (p<0.01) as well as motor skills (p<0.001) were linearly associated with the extent of intrauterine growth deficit when the latter was treated as a continuous variable. To conclude, an increase in intrauterine growth deficit is accompanied by a proportionate decline in quality of developmental outcome in children born to mothers with hypertension in pregnancy. |
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Authors:
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Mindy E Kronenberg; Sarah Raz; Craig J Sander |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 48 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-17 Completed Date: 2006-04-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 200-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Louisiana State University, Health Science Center, New Orleans, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child, Preschool Developmental Disabilities / diagnosis, epidemiology* Female Fetal Growth Retardation / epidemiology* Humans Hypertension, Pregnancy-Induced / epidemiology*, physiopathology* Male Pregnancy Pregnancy Complications / epidemiology* |
| Grant Support | |
ID/Acronym/Agency:
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HD32244/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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