| Neurodevelopmental outcome in 2-year-old infants who were small-for-gestational age term fetuses with cerebral blood flow redistribution. | |
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MedLine Citation:
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PMID: 19035538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the neurodevelopmental outcome at 2 years of age of children who had been small-for-gestational-age (SGA) term babies with cerebral blood flow redistribution. METHODS: Perinatal outcome was assessed in a cohort of 97 term singleton appropriate-for-gestational-age and 125 term singleton SGA fetuses with normal umbilical artery Doppler, stratified according to the presence of cerebral blood flow redistribution. Neurodevelopmental outcome was assessed prospectively at 2 years of age by means of the 24-month Age & Stage Questionnaire (ASQ). RESULTS: Of the 125 SGA fetuses, 25 had redistribution of the cerebral blood flow, and 100 did not. There were no significant differences in perinatal outcome between these two SGA groups. At 2 years of age, children who had been SGA fetuses with middle cerebral artery (MCA) pulsatility index (PI) < 5(th) centile had a higher incidence of suboptimal neurodevelopmental outcome compared with those with normal MCA-PI (52% vs. 31%; P = 0.049) and a lower mean centile in communication (53.1 vs. 67.4; P = 0.006) and problem-solving (39.7 vs. 47.4; P = 0.04) areas. CONCLUSION: SGA fetuses with cerebral blood flow redistribution have a higher risk of subtle neurodevelopmental deficits at 2 years of age. This challenges the concept that fetal cerebral redistribution is an entirely protective mechanism and suggests MCA-PI as a risk stratifying factor for adverse neurodevelopmental outcome. |
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Authors:
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E Eixarch; E Meler; A Iraola; M Illa; F Crispi; E Hernandez-Andrade; E Gratacos; F Figueras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 32 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-02 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 894-9 Citation Subset: IM |
Copyright Information:
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(c) 2008 ISUOG. |
Affiliation:
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Maternal-Fetal Medicine Department, ICGON, Fetal and Perinatal Research Group, IDIBAPS, Hospital Clinic, University of Barcelona, Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrovascular Circulation* Child Development* Child, Preschool Cohort Studies Communication Developmental Disabilities / diagnosis, etiology* Female Humans Infant, Newborn Infant, Small for Gestational Age / growth & development, physiology* Motor Skills Pregnancy Problem Solving Prospective Studies Pulsatile Flow / physiology Questionnaires Social Behavior Ultrasonography, Doppler / instrumentation Ultrasonography, Prenatal / methods |
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