| Neurodevelopmental outcome of full-term, small-for-gestational-age infants with normal placental function. | |
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MedLine Citation:
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PMID: 23303527 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the 2-year neurodevelopmental outcome of full-term, small-for-gestational-age (SGA) newborns with normal placental function, according to current criteria based on umbilical artery Doppler. PATIENTS AND METHODS: A cohort of consecutive full-term, SGA newborns with normal prenatal umbilical artery Doppler was compared with a group of full-term, appropriate-for-gestational-age (AGA) infants sampled from our general neonatal population. Neurodevelopmental outcome was evaluated at 24-months corrected age with the Bayley scale for infant and toddler development, third edition (Bayley-III), which evaluates cognitive, language, motor, social-emotional, and adaptive competencies. The effect of the study group on each domain was adjusted with multiple analysis of covariance and logistic regression for gestational age at delivery, socio-economic status, gender, tobacco smoking, and breastfeeding. RESULTS: A total of 223 infants (111 SGA and 112 AGA) were included. The groups differed significantly on socio-economic status and gestational age at delivery. All studied neurodevelopmental domains were poorer in the SGA group, reaching significance for the cognitive (100.2 vs. 92.9, adjusted p=0.027), language (101 vs. 94.7, adjusted p=0.025), motor (100 vs. 94.2, adjusted p=0.027), and adaptive (96.5 vs. 89.2, adjusted p=0.012) scores. Likewise, the SGA group had a higher risk of low scores in language (odds ratio [OR] 2.63 adjusted p=0.045) and adaptive (OR 2.72 adjusted p=0.009) domains. CONCLUSIONS: Compared to normal sized babies, full-term SGA infants, without currently used criteria defining placental insufficiency, have lower 2-year neurodevelopmental scores. These data challenge the concept that SGA fetuses with normal umbilical artery Doppler are "constitutionally small" and otherwise completely normal. |
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Authors:
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Stefan Savchev; Magda Sanz-Cortes; Cruz-Martinez Rogelio; Angela Arranz; Botet Francesc; Gratacos Eduard; Figueras Francesc |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Perinatal Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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