Document Detail

Neurodevelopmental outcome at 1 year in Zimbabwean neonates with extreme hyperbilirubinaemia.
MedLine Citation:
PMID:  10048606     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Infants with bilirubin levels between 400 and 500 micromol/l (23.4 and 29.2 mg/dl) who scored abnormal or suspect on the Bayley Scales of Infant Development were preterm or had haemolytic disease. All term infants without haemolysis and with bilirubin levels between 400 and 500 micromol/l (23.4 mg/dl-29.2 mg/dl) were normal at 1 year of age.
The effect of maximum total serum bilirubin (TSB) in excess of 400 mcgmol/l (23.4 mg/dl) on neurodevelopmental outcome at 12 months was assessed in a follow-up study of 50 infants admitted to the Special Baby Care Unit of Mpilo Central Hospital in Bulawayo, Zimbabwe. There were 26 preterm infants (52%) in this series. 2 infants died before they reached 12 months of age and 5 were lost to follow-up. TSB levels were not associated with either birth weight or gestational age. Overall, 32 infants (74%) had Bayley Scales of Infant Development scores within the normal range. 11 (26%) of the 43 infants with extreme TSB (above 482 mcgmol/l) had suspect or abnormally low scores on the Bayley Scales and 5 of these infants (12%) developed the choreo-athetoid type of cerebral palsy. The infants with TSB levels of 400-500 mcgmol/l who had suspect or abnormal Bayley scores either had hemolytic disease or were premature. Finally, infants treated with exchange transfusion had higher TSB levels and 67% of transfused newborns demonstrated delayed development at 12 months of age.
M J Wolf; B Wolf; G Beunen; P Casaer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  158     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-16     Completed Date:  1999-04-16     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM; J    
Children's Rehabilitation Unit, Mpilo Central Hospital, Bulawayo, Zimbabwe.
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MeSH Terms
Analysis of Variance
Bilirubin / blood
Birth Weight
Child Development*
Follow-Up Studies
Gestational Age
Infant, Newborn
Jaundice, Neonatal / blood,  ethnology,  psychology*
Risk Factors
Time Factors
Zimbabwe / epidemiology
Reg. No./Substance:

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