Document Detail

Neurodevelopmental outcome of asymptomatic & symptomatic babies with neonatal hypoglycaemia.
MedLine Citation:
PMID:  2071185     Owner:  NLM     Status:  MEDLINE    
A total of 107 babies with hypoglycaemia were studied over a period of 15 months. Symptomatic hypoglycaemia was found in 43 while it was asymptomatic in the others. Asymptomatic hypoglycaemia occurred at a relatively earlier post-natal age (4.5 +/- 2.2 h), as compared to symptomatic hypoglycemia (18.5 +/- 5.4 h, P less than 0.001). The mean blood glucose in hypoglycaemic babies with seizures was found to be significantly lower (P less than 0.001) when compared to those with other features as well as asymptomatic ones. Hypoglycaemia lasted for a significantly longer duration in symptomatic babies as compared to those without symptoms (P less than 0.001). On neurodevelopment follow up the mental developmental index (MDI) and the psychomotor developmental index (PDI) of symptomatic babies with seizures were significantly lower (P less than 0.001) as compared to those with other features of hypoglycaemia as well as asymptomatic babies. The neurodevelopmental status of babies with symptoms other than seizures was also significantly poorer (P less than 0.001), when compared to asymptomatic hypoglycaemic babies. The duration of hypoglycaemia was directly related to the MDI (r = -0.74, y = 102.5 - 0.69x) and PDI (r = -0.81, y = 105.6 - 0.86x). This study indicates that there is a need to identify babies vulnerable to symptomatic hypoglycaemia more precisely.
M Singh; P K Singhal; V K Paul; A K Deorari; K R Sundaram; M D Ghorpade; A Agadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  94     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-08-20     Completed Date:  1991-08-20     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Hypoglycemia / physiopathology*
Infant, Newborn
Infant, Newborn, Diseases / physiopathology*
Motor Activity / physiology
Nervous System / growth & development*

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