Document Detail

Neurodevelopmental outcome after COX inhibitor treatment for patent ductus arteriosus.
MedLine Citation:
PMID:  20153127     Owner:  NLM     Status:  MEDLINE    
AIM: To compare neurodevelopmental results in very low birth weight (VLBW) infants two years after successful or failed cyclooxygenase inhibitor treatment with either indomethacin or ibuprofen for a haemodynamically significant patent ductus arteriosus (hsPDA). METHODS: We retrospectively evaluated closure rates and outcome parameters of VLBW infants with hsPDA 89 of whom were treated with indomethacin and 93 with ibuprofen. RESULTS: Indomethacin and ibuprofen therapy groups did not differ in their baseline clinical profile (median gestational age 26.0 and 26.2wksd) in early (median CRIB 6 and 5, respiratory distress >2 degrees in 36 and 34 infants) and late morbidities (intraventricular hemorrhage >2 degrees in 9 and 10 infants, bronchopulmonary dysplasia in 31 and 27 infants, 80 and 85 survivors), PDA closure rates (63 and 58%) or neurodevelopmental outcome. The therapy failure group (54 infants) was characterized by lower median gestational age (25.0wksd) and higher mortality (17%). No differences were found in the neurodevelopmental outcome of the surviving infants with ligation as compared to the survivors with successful pharmacological closure of the PDA at 24months corrected age. CONCLUSION: Use of either ibuprofen or indomethacin for closure of a hsPDA did not influence two year neurodevelopmental outcomes in VLBW infants.
C Rheinlaender; D Helfenstein; C Pees; E Walch; C Czernik; M Obladen; P Koehne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-12
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Department of Neonatology, Charit?, Universit?tsmedizin Berlin, Campus Virchow-Klinikum, Germany.
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MeSH Terms
Central Nervous System / drug effects*,  growth & development
Child Development / drug effects,  physiology
Child, Preschool
Cyclooxygenase Inhibitors / therapeutic use*
Ductus Arteriosus, Patent / drug therapy*
Gestational Age
Ibuprofen / therapeutic use*
Indomethacin / therapeutic use*
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Psychomotor Performance / drug effects,  physiology
Retrospective Studies
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 15687-27-1/Ibuprofen; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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