Document Detail

Neurodevelopmental outcomes of extremely low birth weight infants ventilated with continuous positive airway pressure vs. mechanical ventilation.
MedLine Citation:
PMID:  21853318     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare continuous positive airway pressure (CPAP) vs. traditional mechanical ventilation (MV) at 24 h of age as predictors of neurodevelopmental (ND) outcomes in extremely low birth weight (ELBW) infants at 18-22 months corrected gestational age (CGA).
METHODS: Infants ≤1000 g birth weight born from January 2000 through December 2006 at two hospitals at the Cincinnati site of the National Institute of Child Health and Human Development Neonatal Research Network were evaluated comparing CPAP (n = 198) vs. MV (n = 109). Primary outcomes included the Bayley Score of Infant Development Version II (BSID-II), presence of deafness, blindness, cerebral palsy, bronchopulmonary dysplasia and death.
RESULTS: Ventilatory groups were similar in gender, rates of preterm prolonged rupture of membranes, antepartum hemorrhage, use of antenatal antibiotics, steroids, and tocolytics. Infants receiving CPAP weighed more, were older, were more likely to be non-Caucasian and from a singleton pregnancy. Infants receiving CPAP had better BSID-II scores, and lower rates of BPD and death.
CONCLUSIONS: After adjusting for acuity differences, ventilatory strategy at 24 h of age independently predicts long-term neurodevelopmental outcome in ELBW infants.
Cameron W Thomas; Jareen Meinzen-Derr; Steven B Hoath; Vivek Narendran
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-08-19
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  79     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-05-29     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
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MeSH Terms
Continuous Positive Airway Pressure
Developmental Disabilities / epidemiology*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Nervous System Diseases / epidemiology*
Respiration, Artificial*
Retrospective Studies
Grant Support

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