Document Detail

Neurodevelopmental follow-up at five years corrected age of extremely low birth weight infants after postnatal replacement of 17β-estradiol and progesterone.
MedLine Citation:
PMID:  22259065     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Extremely low birth weight (ELBW) infants are prone to impaired neurodevelopment.
OBJECTIVE: The aim was to determine long-term neurodevelopmental outcome in ELBW infants after postnatal 17β-estradiol (E2) and progesterone (P) replacement.
DESIGN: At 5-yr corrected age, ELBW infants were assessed for standardized cognitive and neurological outcome after postnatal randomized E2 and P replacement or placebo administration.
SETTING: The follow-up examination was performed in a neuropediatric ambulatory care center.
PATIENTS: Sixty-one of 71 surviving infants (86%) were available for follow-up.
MAIN OUTCOME MEASURES: Cognitive and neurological outcome was evaluated using the Kaufmann Assessment Battery for Children, the Gross Motor Function Classification Scale, and clinical neurological examination.
RESULTS: No significant differences were found between the replacement and placebo groups for the Gross Motor Function Classification Scale, presence of paresis, cerebral palsy, spasticity, and ametropia. However, a significant time-response relationship was found with E2 and P replacement. Every day of treatment reduced the risk for cerebral palsy (P=0.03), spasticity (P=0.01), and ametropia (P=0.01).
CONCLUSION: Postnatal E2 and P replacement may have potential in improving neurodevelopmental outcome in ELBW infants. Larger trials are needed to test this new hypothesis.
Andreas Trotter; Jochen Steinmacher; Martina Kron; Frank Pohlandt
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-01-18
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  97     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-07-06     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-7     Citation Subset:  AIM; IM    
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MeSH Terms
Child Development / drug effects,  physiology*
Child, Preschool
Double-Blind Method
Estradiol / therapeutic use*
Follow-Up Studies
Hormone Replacement Therapy / methods*
Infant, Extremely Low Birth Weight / growth & development*
Infant, Newborn
Progesterone / therapeutic use*
Treatment Outcome
Reg. No./Substance:
4G7DS2Q64Y/Progesterone; 4TI98Z838E/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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