| Neurodevelopmental Follow-Up at Five Years Corrected Age of Extremely Low Birth Weight Infants after Postnatal Replacement of 17β-Estradiol and Progesterone. | |
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MedLine Citation:
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PMID: 22259065 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Extremely low birth weight (ELBW) infants are prone to impaired neurodevelopment.Objective:The aim was to determine long-term neurodevelopmental outcome in ELBW infants after postnatal 17β-estradiol (E2) and progesterone (P) replacement.Design:At 5-yr corrected age, ELBW infants were assessed for standardized cognitive and neurological outcome after postnatal randomized E2 and P replacement or placebo administration.Setting:The follow-up examination was performed in a neuropediatric ambulatory care center.Patients:Sixty-one of 71 surviving infants (86%) were available for follow-up.Main Outcome Measures:Cognitive and neurological outcome was evaluated using the Kaufmann Assessment Battery for Children, the Gross Motor Function Classification Scale, and clinical neurological examination.Results:No significant differences were found between the replacement and placebo groups for the Gross Motor Function Classification Scale, presence of paresis, cerebral palsy, spasticity, and ametropia. However, a significant time-response relationship was found with E2 and P replacement. Every day of treatment reduced the risk for cerebral palsy (P = 0.03), spasticity (P = 0.01), and ametropia (P = 0.01).Conclusion:Postnatal E2 and P replacement may have potential in improving neurodevelopmental outcome in ELBW infants. Larger trials are needed to test this new hypothesis. |
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Authors:
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Andreas Trotter; Jochen Steinmacher; Martina Kron; Frank Pohlandt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Perinatal Medicine (A.T.), Children's Hospital, University of Bonn, 53105 Bonn, Germany; and Section of Neonatology and Pediatric Critical Care, Children's Hospital (J.S., F.P.), and Department of Biometry and Medical Documentation (M.K.), University of Ulm, 89075 Ulm, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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