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Neurodevelopmental Follow-Up at Five Years Corrected Age of Extremely Low Birth Weight Infants after Postnatal Replacement of 17β-Estradiol and Progesterone.
MedLine Citation:
PMID:  22259065     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:Extremely low birth weight (ELBW) infants are prone to impaired neurodevelopment.Objective:The aim was to determine long-term neurodevelopmental outcome in ELBW infants after postnatal 17β-estradiol (E2) and progesterone (P) replacement.Design:At 5-yr corrected age, ELBW infants were assessed for standardized cognitive and neurological outcome after postnatal randomized E2 and P replacement or placebo administration.Setting:The follow-up examination was performed in a neuropediatric ambulatory care center.Patients:Sixty-one of 71 surviving infants (86%) were available for follow-up.Main Outcome Measures:Cognitive and neurological outcome was evaluated using the Kaufmann Assessment Battery for Children, the Gross Motor Function Classification Scale, and clinical neurological examination.Results:No significant differences were found between the replacement and placebo groups for the Gross Motor Function Classification Scale, presence of paresis, cerebral palsy, spasticity, and ametropia. However, a significant time-response relationship was found with E2 and P replacement. Every day of treatment reduced the risk for cerebral palsy (P = 0.03), spasticity (P = 0.01), and ametropia (P = 0.01).Conclusion:Postnatal E2 and P replacement may have potential in improving neurodevelopmental outcome in ELBW infants. Larger trials are needed to test this new hypothesis.
Authors:
Andreas Trotter; Jochen Steinmacher; Martina Kron; Frank Pohlandt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre for Perinatal Medicine (A.T.), Children's Hospital, University of Bonn, 53105 Bonn, Germany; and Section of Neonatology and Pediatric Critical Care, Children's Hospital (J.S., F.P.), and Department of Biometry and Medical Documentation (M.K.), University of Ulm, 89075 Ulm, Germany.
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