Document Detail


Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA positive mothers.
MedLine Citation:
PMID:  23057469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To define factors influencing neurodevelopment in children with and without complete congenital heart block (CHB) born to mothers with Ro/SSA autoantibodies. PATIENTS AND METHODS: Medical records of a population-based cohort of siblings with (n=60) and without (n=54) CHB born 1974-2009 to anti-Ro/SSA positive mothers were retrieved from children primary health care centers and school health services and used to extract data on neurodevelopment. RESULTS: Impaired neurodevelopment was reported in 16% of the children (18/114) during the follow-up time of 13.0 (8.2-17.5) years, median (quartiles). Reported problems included speech (9%), motor (8%) and learning (8%) impairment, attention deficit (5%) and behavioral impairment (4%). Impairment of motor skill development was more common in boys (p<0.001) and if the child was born preterm (p<0.001). Learning impairment was significantly influenced by maternal SLE (p<0.005), while attention deficits was influenced by both maternal SLE (p<0.05) and CHB in the child (p<0.05). CONCLUSIONS: Our data indicate that in addition to well established factors such as male sex and being born preterm, both maternal SLE and CHB may influence neurodevelopment. Follow-up of neurodevelopment should therefore be considered for children with CHB, especially if the mother is diagnosed with SLE. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Authors:
Amanda Skog; Joanna Tingström; Stina Salomonsson; Sven-Erik Sonesson; Marie Wahren-Herlenius
Related Documents :
24455219 - The effect of a maternal double megadose of vitamin a supplement on serum levels of ret...
11722959 - Prevalence of iron deficiency with and without concurrent anemia in population groups w...
1861459 - Successful treatment of dihydropteridine reductase deficiency, with an interesting effe...
16335779 - Anaemia among schoolchildren in qena governorate, upper egypt.
16426959 - Effect of micronutrient supplement on health and nutritional status of schoolchildren: ...
3204329 - Hemolytic anemia and susceptibility to hydrogen-peroxide hemolysis in children with vit...
6725569 - Eye color as a predictor of outcomes in behavior therapy.
12604019 - Leishmania antibodies in children’s serum samples in correlation with the disease in d...
10829929 - Empty sella in short children with and without hypothalamic-pituitary abnormalities.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Affiliation:
Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The implementation of a tobacco dependence education curriculum in a Swiss Dental Hygiene School - a...
Next Document:  Acinetobacter baumannii isolates associated with community-acquired pneumonia in West China.