Document Detail


Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA positive mothers.
MedLine Citation:
PMID:  23057469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To define factors influencing neurodevelopment in children with and without complete congenital heart block (CHB) born to mothers with Ro/SSA autoantibodies. PATIENTS AND METHODS: Medical records of a population-based cohort of siblings with (n=60) and without (n=54) CHB born 1974-2009 to anti-Ro/SSA positive mothers were retrieved from children primary health care centers and school health services and used to extract data on neurodevelopment. RESULTS: Impaired neurodevelopment was reported in 16% of the children (18/114) during the follow-up time of 13.0 (8.2-17.5) years, median (quartiles). Reported problems included speech (9%), motor (8%) and learning (8%) impairment, attention deficit (5%) and behavioral impairment (4%). Impairment of motor skill development was more common in boys (p<0.001) and if the child was born preterm (p<0.001). Learning impairment was significantly influenced by maternal SLE (p<0.005), while attention deficits was influenced by both maternal SLE (p<0.05) and CHB in the child (p<0.05). CONCLUSIONS: Our data indicate that in addition to well established factors such as male sex and being born preterm, both maternal SLE and CHB may influence neurodevelopment. Follow-up of neurodevelopment should therefore be considered for children with CHB, especially if the mother is diagnosed with SLE. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Authors:
Amanda Skog; Joanna Tingström; Stina Salomonsson; Sven-Erik Sonesson; Marie Wahren-Herlenius
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Affiliation:
Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
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