Document Detail

Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression.
MedLine Citation:
PMID:  23128923     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Effects on child neurodevelopment of neurotransmitter reuptake inhibitors used as antidepressants during pregnancy have not been adequately studied. The authors compared the effects of prenatal exposure to venlafaxine (serotonin-norepinephrine reuptake inhibitor), selective serotonin reuptake inhibitors (SSRIs), and maternal depression.
METHOD: A cohort derived from a prospectively collected database included four groups of children born to 1) depressed women who took venlafaxine during pregnancy (N=62), 2) depressed women who took SSRIs during pregnancy (N=62), 3) depressed women who were untreated during pregnancy (N=54), and 4) nondepressed, healthy women (N=62). The children's intelligence and behavior outcomes were evaluated with standardized instruments at one time point between the ages of 3 years and 6 years, 11 months.
RESULTS: The children exposed to venlafaxine, SSRIs, and maternal depression during pregnancy had similar full-scale IQs (105, 105, and 108, respectively). The IQs of the venlafaxine and SSRI groups were significantly lower than that of the children of nondepressed mothers (112). The three groups exposed to maternal depression had consistently, but nonsignificantly, higher rates of most problematic behaviors than the children of nondepressed mothers. Severity of maternal depression in pregnancy and at testing predicted child behavior. Maternal IQ and child sex predicted child IQ. Antidepressant dose and duration during pregnancy did not predict any cognitive or behavioral outcome.
CONCLUSIONS: Factors other than antidepressant exposure during pregnancy strongly predict children's intellect and behavior. Depression during pregnancy is a significant risk factor for postpartum depression. Children of depressed mothers may be at risk of future psychopathology.
Irena Nulman; Gideon Koren; Joanne Rovet; Maru Barrera; Ariel Pulver; David Streiner; Brian Feldman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  169     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-03-27     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1165-74     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Drug-Induced / diagnosis*,  physiopathology
Antidepressive Agents, Second-Generation / adverse effects*,  therapeutic use
Case-Control Studies
Child Behavior Disorders / chemically induced*,  physiopathology*
Child, Preschool
Cyclohexanols / adverse effects*,  therapeutic use
Depressive Disorder / drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Infant, Newborn
Intelligence / drug effects*,  physiology*
Longitudinal Studies
Neonatal Abstinence Syndrome / diagnosis*,  physiopathology
Pregnancy Complications / drug therapy*,  physiopathology
Prenatal Exposure Delayed Effects*
Prospective Studies
Reference Values
Retrospective Studies
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Sex Factors
Wechsler Scales
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Cyclohexanols; 0/Serotonin Uptake Inhibitors; GRZ5RCB1QG/venlafaxine
Comment In:
Am J Psychiatry. 2012 Nov;169(11):1130-2   [PMID:  23128917 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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