Document Detail

Neurodevelopment at 1 year of age in infants with congenital heart disease.
MedLine Citation:
PMID:  12639876     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess psychomotor development and neurological sequelae in infants after surgery for congenital heart defects.
DESIGN AND SETTING: Single institution prospective cohort study.
PATIENTS: 90 of 112 consecutive surviving infants of less than 1 year of age, without brain anomalies, conditions, or syndromes associated with delayed mental development, who underwent cardiac surgery during an 18 month period; 20 control infants with minor or no congenital heart defects.
MAIN OUTCOME MEASURES: Griffiths developmental scales and standardised neurological examination at 1 year.
RESULTS: Mean (SD) developmental quotient (DQ) in index infants was 99 (10.6), compared with 106.7 (6.6) in controls (p < 0.001). DQ was lower in infants after palliative surgery (n = 16; 88 (12.2)) than after corrective surgery (n = 74; 101.4 (8.6)) (p < 0.001). Of the 90 index infants, 24 (27%) had a DQ below 93.5 (more than 2 SD below the mean of controls). Developmental delay (DQ < 93.5) was more common after palliative surgery (10/16, 63%) than after corrective surgery (14/74, 19%) (p < 0.001). Of the 90 index infants, 29 (32%) had neurological abnormalities, compared with only one of the 20 controls (5%) (p = 0.013). Neurological abnormalities were more frequent after palliative surgery (11/16, 69%) than after corrective surgery (18/74, 24%) (p < 0.001).
CONCLUSIONS: There is a considerable rate of neurodevelopmental impairment at 1 year of age in infants after cardiac surgery. Psychomotor impairment and neurological sequelae are apparently more severe in infants in whom only palliative surgery is possible.
H Dittrich; C Bührer; I Grimmer; S Dittrich; H Abdul-Khaliq; P E Lange
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  89     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-04-02     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-41     Citation Subset:  AIM; IM    
Department of Congenital Heart Defects, German Heart Institute, Berlin, Germany.
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MeSH Terms
Cohort Studies
Developmental Disabilities / etiology*
Heart Defects, Congenital / surgery*
Infant, Newborn
Neurologic Examination
Postoperative Care / methods
Postoperative Complications / etiology*
Prospective Studies
Psychomotor Disorders / etiology*
Comment In:
Heart. 2003 Apr;89(4):365-6   [PMID:  12639856 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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