| Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis. | |
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MedLine Citation:
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PMID: 8859278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with a large congenital melanocytic nevus (LCMN) may have associated leptomeningeal melanocytosis with or without central nervous system (CNS) melanomas. These patients are considered to have neurocutaneous melanosis, a disorder that, when symptomatic or otherwise manifest neurologically, carries a poor prognosis even in the absence of malignancy. OBJECTIVE: Our purpose was to identify typical clinical features in patients who have manifest CNS melanosis in association with LCMN. METHODS: The records of 117 patients with LCMN in the New York University Registry of LCMN and the reports of 172 cases of LCMN in the world literature were included for features that might signal a high risk for the development of manifest CNS involvement. RESULTS: Of the 289 patients with LCMN, 33 had manifest CNS melanosis. In all 33 in whom symptomatic neurocutaneous melanosis was diagnosed, the LCMNs were present in a posterior axial location on the head, neck, back, and/or buttocks. "Satellite" nevi were known to be present in 31 of the 33 patients. CONCLUSION: Patients with LCMN in a posterior axial location, especially when associated with "satellite" melanocytic nevi, are at greater risk for the development of manifest neurocutaneous melanosis than patients with LCMN limited to the extremities or those who are lacking satellite nevi. |
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Authors:
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M DeDavid; S J Orlow; N Provost; A A Marghoob; B K Rao; Q Wasti; C L Huang; A W Kopf; R S Bart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 35 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-19 Completed Date: 1996-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 529-38 Citation Subset: IM |
Affiliation:
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Ronald O. Pereiman Department of Dermatology, New York University School of Medicine, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arachnoid / pathology Back / pathology Buttocks / pathology Central Nervous System Diseases / complications*, pathology Child Child, Preschool Female Head and Neck Neoplasms / congenital, pathology Humans Infant Male Melanosis / complications*, pathology Middle Aged Nevus, Pigmented / congenital*, pathology Pia Mater / pathology Prognosis Registries Retrospective Studies Risk Factors Skin Neoplasms / congenital*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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5P30 CA-16087-18/CA/NCI NIH HHS |
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