Document Detail

Neurocognitive profiles of people with borderline personality disorder.
MedLine Citation:
PMID:  23196999     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: This review summarizes recent neurocognitive research to better delineate the nosology, prognostication and cause underlying borderline personality disorder (BPD).
RECENT FINDINGS: BPD had marked clinical heterogeneity with high comorbidity. Executive dysfunction in this disorder was linked to suicidality and treatment adherence, and may serve as an endophenotype. BPD was also characterized by cognitive distortions such as risky decision-making, deficient feedback processing, dichotomous thinking, jumping to conclusion, monocausal attribution and paranoid cognitive style. Social cognition deficits recently described in BPD include altered social inference and emotional empathy, hypermentalization, poorer facial emotional recognition and facial expressions. In electrophysiological studies, BPD was found to have predominantly right hemispheric deficit in high-order cortical inhibition. Reduced left orbitofrontal activity by visual evoked potential and magnetoencephalography correlated with depressive symptoms and functional deterioration. Brain structures implicated in BPD include the hippocampus, dorsolateral prefrontal cortex and anterior cingulate cortex. Abnormal anatomy and functioning of frontolimbic circuitry appear to correlate with cognitive deficits.
SUMMARY: Frontolimbic structural and functional abnormalities underlie the broad array of cognitive abnormalities in BPD. Further research should espouse broader considerations of effects of comorbidity and clinical heterogeneity, and include community samples and, possibly, longitudinal designs.
Arthur D P Mak; Linda C W Lam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in psychiatry     Volume:  26     ISSN:  1473-6578     ISO Abbreviation:  Curr Opin Psychiatry     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809880     Medline TA:  Curr Opin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-6     Citation Subset:  IM    
Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR.
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