Document Detail

Neurocognitive impairment in Chinese patients with obstructive sleep apnoea hypopnoea syndrome.
MedLine Citation:
PMID:  21507144     Owner:  NLM     Status:  Publisher    
Background and objective:  Sleep disordered breathing is known to be associated with impairment in cognitive function. The aim of this study was to characterize neurocognitive impairment in a cohort of Chinese patients with varying severities of obstructive sleep apnoea hypopnoea syndrome (OSAHS), and to develop a sensitive instrument for routine screening of cognitive impairment. Methods:  Eligible patients (n= 394) were categorized into a primary snoring group, and mild, moderate and severe OSAHS groups, based on assessment of AHI. The Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) questionnaires were administered to assess cognitive function, and the correlations between questionnaire scores and clinical and polysomnographic parameters were further evaluated by stepwise multivariate regression. Results:  MoCA scores decreased progressively across the spectrum from primary snoring to severe OSAHS. Importantly, mild neurocognitive impairment as defined by a MoCA score <26 was more common in the moderate (38.6%) and severe (41.4%) OSAHS groups than in the mild OSAHS (25.0%) and primary snoring (15.2%) groups. In contrast, MMSE scores were largely normal and comparable among all four groups. Evaluation of MoCA subdomains further revealed selective reduction in memory/delayed recall, visuospatial and executive function, and attention span in the severe OSAHS group compared with the other groups. Stepwise multivariate regression analysis demonstrated that MoCA scores correlated significantly with lowest oxygen saturation (L-SaO(2) ) and years of education. Conclusions:  Neurocognitive impairment is common in patients with OSAHS. The MoCA is a brief and sensitive tool for the assessment of cognitive impairment in OSAHS patients, whose performance on the MMSE is in the normal range. SUMMARY AT A GLANCE: This study compared MoCA and MMSE for assessing cognitive function in OSAHS patients. OSAHS was frequently associated with neurocognitive impairment that was detected with MoCA but not MMSE. MoCA scores correlated with disease severity and polysomnographic parameters. MoCA is a rapid sensitive tool for detecting cognitive impairment in OSAHS.
Rui Chen; Kang-Ping Xiong; Juan-Ying Huang; Yi-Xin Lian; Fa Jin; Zhen-Hua Li; Min-Yan Zhao; Chun-Feng Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology.
Sleep Center, Department of Respiratory Medicine, Second Affiliated Hospital of Soochow University, and Laboratory of Aging and Nervous Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
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