Document Detail


Neurocognitive dysfunction in the eosinophilia-myalgia syndrome.
MedLine Citation:
PMID:  8492948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The eosinophilia-myalgia syndrome (EMS), a multisystem disorder associated with ingestion of L-tryptophan-containing products, causes sclerodermatous skin changes, cardiopulmonary disease, and a range of peripheral neurologic complications. Many EMS patients also report cognitive difficulty in association with the disease. To determine the frequency of objective neurocognitive impairment in EMS patients with subjective complaints of cognitive difficulty and to assess the relationship of neurocognitive loss with demographic features, degree of peripheral eosinophilia, and psychiatric diagnosis, we compared 24 EMS patients with 32 age- and education-matched healthy controls, using a comprehensive neuropsychological test battery. EMS patients additionally underwent a psychiatric interview and rheumatologic evaluation. Sixty-two percent (15 of 24) of the EMS patients demonstrated neurocognitive deficits. Compared with healthy controls, EMS patients demonstrated significant impairment on tests of verbal memory, visual memory, conceptual reasoning, and motor speed. Cognitively impaired EMS patients did not differ from those without cognitive impairment on demographic markers, degree of peripheral eosinophilia, presence of peripheral neuropathy, or frequency of concurrent psychiatric disorder, including major depression. These data support the hypothesis that EMS is associated with an encephalopathy in addition to its previously recognized peripheral neuropathy and other rheumatologic manifestations.
Authors:
L B Krupp; D M Masur; L D Kaufman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, State University of New York, Stony Brook 11794.
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MeSH Terms
Descriptor/Qualifier:
Attention
Cognition Disorders / etiology*,  psychology
Drug Contamination
Eosinophilia-Myalgia Syndrome / physiopathology*,  psychology*
Female
Humans
Male
Memory
Middle Aged
Motor Activity
Psychological Tests
Tryptophan*
Grant Support
ID/Acronym/Agency:
R01 AI31561-01A1/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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