Document Detail

Neurocognitive assessments in advanced heart failure patients receiving continuous-flow left ventricular assist devices.
MedLine Citation:
PMID:  19481013     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neurocognitive (NC) changes in heart failure patients receiving left ventricular assist devices (LVADs) are not well understood. The purpose of this study was to document changes in the cognitive performance of patients with the continuous-flow HeartMate II LVAD as a bridge to transplant (BTT). METHODS: A NC protocol was used to evaluate patient performance at 1, 3 and 6 months after LVAD implantation at 11 centers. A total of 239 test sessions were completed in 93 patients including paired evaluations in 51 to 57 patients from 1 to 3 months, and in 20 to 28 patients with results from 1, 3 and 6 months. Five NC domains were assessed, including visual spatial perception, auditory and visual memory, executive functions, language and processing speed. RESULTS: There were statistically significant (p < 0.05), but limited improvements between 1, 3 and 6 months in NC domain performances as seen in visual memory, executive functions, visual spatial perception and processing speed. There were no significant declines in any neurocognitive test in any domain over these time periods. CONCLUSIONS: The cognitive performance of advanced heart failure patients remained stable or showed slight improvements from Month 1 to Month 6 of continuous-blood-flow support with the HeartMate II LVAD.
Ralph J Petrucci; Susan Wright; Yoshifuma Naka; Kathy A Idrissi; Stuart D Russell; Dzifa Dordunoo; Brian Jaski; Suzanne Chillcott; David Feldman; Tammy Yanssens; Gerald Heatley; Lalig Koundakjian; David J Farrar; Keith D Aaronson;
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  28     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-9     Citation Subset:  IM    
Department of Psychiatry, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA.
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MeSH Terms
Cognition / physiology*
Heart Failure / physiopathology,  psychology*,  surgery*
Heart Transplantation
Heart Ventricles / physiopathology
Heart-Assist Devices* / adverse effects
Memory / physiology
Middle Aged
Prospective Studies
Psychological Tests
Regional Blood Flow / physiology
Time Factors
Treatment Outcome
Ventricular Dysfunction, Left / physiopathology,  psychology*,  surgery*
Visual Perception / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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