| Neurocognitive function in patients with β-thalassemia major. | |
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MedLine Citation:
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PMID: 20964788 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Children with β-thalassemia major (β-TM) have multiple risk factors for developing cognitive impairment. The aim of the present study was to evaluate cognitive function in patients with β-TM. Methods: Twenty children with β-TM were enrolled into the study and were compared with a control group consisting of 21 healthy children. All participants were evaluated with neuropsychological tests and event-related potentials (ERP). Results: All of the participants had normal IQ scores, but the patient group had significantly lower full-scale, performance, and verbal IQs compared with the control group (P < 0.05). The number of children with visuomotor dysfunction was higher in the patient group compared with the control group (P < 0.05). In the P300 test, the patient group had significantly prolonged N1, P2 and N2 latencies at the FZ, and a prolonged N1 latency at the Cz compared with the control group (P < 0.05). The patient group also had lower N1 and P3N4 amplitudes at the Fz, and lower N1, N1P2 and P3N4 amplitudes at the Cz when compared with the control group (P < 0.05). Mismatch negativity latency and duration were longer in the patient group (P < 0.05). Conclusions: Neuropsychological tests are safe, and reliable for the diagnosis of cognitive impairment in β-TM patients, and the use of ERP may facilitate early diagnosis. The number of β-TM patients in the present study was limited, however, and larger numbers of patients are required in further studies. |
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Authors:
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Ozgur Duman; Sema Arayici; Cigil Fettahoglu; Nurkan Eryilmaz; Sibel Ozkaynak; Akif Yesilipek; Volkan Hazar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 53 ISSN: 1442-200X ISO Abbreviation: Pediatr Int Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 519-23 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society. |
Affiliation:
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Departments of Pediatric Neurology Pediatric Hematology and Oncology and Bone Marrow Transplant Unit Child and Adolescent Psychiatry Neurology, Faculty of Medicine, Akdeniz University, Antalya, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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