Document Detail

Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder.
MedLine Citation:
PMID:  19531109     Owner:  NLM     Status:  MEDLINE    
AIM: To date, despite possible neuroanatomical importance, no magnetic resonance spectroscopy (MRS) study on hippocampus has been performed in obsessive-compulsive disorder (OCD). The purpose of the present study was therefore to compare hippocampal chemicals in patients with OCD with those in healthy subjects with no psychopathology. METHODS: Eighteen patients meeting DSM-IV criteria for OCD and 18 healthy controls were studied. The patients and controls underwent proton magnetic resonance spectroscopy ((1)H-MRS), and measures of N-acetyl-l-aspartate (NAA), choline (CHO), and creatine (CRE) in hippocampal regions were obtained. RESULTS: Both NAA/CRE and NAA/CHO ratios in the hippocampus in patients with OCD were reduced relative to healthy controls. The anova showed a near-significant effect of diagnosis for NAA/CRE and a significant effect for NAA/CHO, but the anova did not show any significant effect even at a trend level for CHO/CRE. No main effect of hemisphere was found for any metabolite ratio. CONCLUSIONS: The presence of neuronal degeneration is suggested in OCD. Future longitudinal neuroimaging and neuropsychological studies with larger patient samples are warranted in order to confirm these preliminary findings to better characterize the relevance of neurochemical abnormalities in hippocampus in the pathophysiology of OCD.
Murad Atmaca; Hanefi Yildirim; Huseyin Ozdemir; Mustafa Koc; Sinan Ozler; Ertan Tezcan
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-06-15
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  63     ISSN:  1440-1819     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Department of Psychiatry, School of Medicine, Firat University, Elazig, Turkey.
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MeSH Terms
Analysis of Variance
Aspartic Acid / analogs & derivatives*,  metabolism
Brain / metabolism
Choline / metabolism
Creatine / metabolism
Functional Laterality / physiology
Hippocampus / chemistry,  metabolism*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy / statistics & numerical data*
Nerve Degeneration / diagnosis,  metabolism
Obsessive-Compulsive Disorder / diagnosis*,  metabolism*
Psychiatric Status Rating Scales
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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